Key result
In rabbits, limited infection with P[14] human rotavirus strains provided complete protection from homologous challenge, suggesting VP4 and VP7 are involved in host range restriction.
In the rabbit model of rotavirus infection, host range restriction is complex and involves multiple viral proteins including VP4, VP7, and NSP1.
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No immediate implications for human rotavirus vaccines; leaves open VP4/VP7 contributions to host range restriction.
Ciarlet et al. (1998) studied Rotavirus infection. Rotavirus strains (P[14] HRVs, RRV, and RRV reassortants) vs. Homologous ALA strain was evaluated on Virus shedding and protection from challenge. In rabbits, limited infection with P[14] human rotavirus strains provided complete protection from homologous challenge, suggesting VP4 and VP7 are involved in host range restriction.
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