Key result
Smoking three cigarettes per hour over 5.5 hours induced a rise in systolic blood pressure (median rise 10 vs 1 mmHg, p=0.05) and heart rate, while vascular leakage and GFR remained unaltered.
Why the study?
Does acute heavy smoking alter systemic hemodynamics, kidney function, and endothelial function in normotensive insulin-dependent diabetic patients with microalbuminuria?
Population
9 normotensive insulin-dependent diabetic patients with microalbuminuria, who had been smoking for 19 years.
Comparison
Smoking three cigarettes per hour during a… vs Non-smoking day (cross-over design)
Design
RCT, randomized cross-over design, open
Follow-up
5.5 hours
Authors
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Alerts clinicians to acute BP/HR rises from heavy smoking in microalbuminuric diabetes; confirms no immediate GFR or leakage alterations.
RCT (n=9)
Open-label
cross-over
Does acute heavy smoking alter systemic hemodynamics, kidney function, and endothelial function in normotensive insulin-dependent diabetic patients with microalbuminuria?
Absolute Event Rate: 10% vs 1%
p-value: p=0.05
Acute heavy smoking increases systolic blood pressure and heart rate but does not acutely alter glomerular filtration or albumin leakage in diabetic patients with microalbuminuria.
Hansen et al. (1996) conducted an RCT in insulin-dependent diabetes with microalbuminuria (n=9). Smoking vs. non-smoking was evaluated on rise in systolic blood pressure (mmHg) (p=0.05). Smoking three cigarettes per hour over 5.5 hours induced a rise in systolic blood pressure (median rise 10 vs 1 mmHg, p=0.05) and heart rate, while vascular leakage and GFR remained unaltered.
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