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June 10, 2026Alzheimer s Research & TherapyOpen Access

Plasma p-tau as a biomarker for the differential diagnosis of Alzheimer’s disease: a systematic review and meta-analysis

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Authors

LCLinsong ChaiFujian University of Traditional Chinese MedicineYZYing ZhanFujian University of Traditional Chinese MedicineYHYunshi HuangFujian University of Traditional Chinese Medicine

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Overview

Systematic review reveals plasma p-tau217 offers high diagnostic accuracy for Alzheimer's disease, indicating clinical implications.

Key Points

  • This research aims to evaluate the diagnostic accuracy of plasma phosphorylated tau isoforms in differentiating Alzheimer's disease from other neurodegenerative dementias.
  • Conducted a systematic review and meta-analysis of studies comparing blood p-tau levels in Alzheimer's disease vs. non-Alzheimer's disorders.
  • Synthesized data using bivariate random-effects models for pooled sensitivity, specificity, and diagnostic measures.
  • Included 33 studies with a total of 6,138 participants.
  • Plasma p-tau217 showed superior diagnostic performance with an area under the curve (AUC) of 0.95 and sensitivity of 0.93.
  • Plasma p-tau biomarkers had an overall accuracy AUC of 0.90, with a high positive likelihood ratio (PLR) of 3.77.
  • Plasma assays (AUC 0.92) significantly outperformed serum methods (AUC 0.76), with distinct confidence intervals.

Cite This Study

Chai et al. (2026) studied this question.

synapsesocial.com/papers/6a28fe326f82f25be989b9e2https://doi.org/10.1186/s13195-026-02104-6
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