What question did this study set out to answer?

The study aims to evaluate haematological abnormalities in hepatitis B virus (HBV) infection and examine the diagnostic value of blood cell indices in this context.

June 10, 2026Journal of Umm Al-Qura University for Medical SciencesOpen Access

Haematological alterations and diagnostic performance of blood cell indices in hepatitis B virus infection in Edo-North, Nigeria: a comparative cross-sectional study

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The study aims to evaluate haematological abnormalities in hepatitis B virus (HBV) infection and examine the diagnostic value of blood cell indices in this context.
Quantitative comparative cross-sectional study conducted with 400 participants (200 HBV-infected, 200 healthy controls).
Haematological parameters measured using an automated analyser; HBV confirmed through HBsAg testing.
Statistical analyses included normality testing, t-tests, Mann–Whitney U tests, and receiver operating characteristic curve analysis.
HBV-infected participants had significantly lower HCT, HGB, PLT, RBC, LYM, MCV, MCH, and MCHC, and higher WBC, MONO, and GRAN counts (all p < 0.001).
Anaemia occurred in 23.0%, thrombocytopenia in 18.5%, and leucopenia in 16.5% of participants.
Haemoglobin showed moderate-to-good discriminative ability for severity (AUC = 0.72–0.77); RBC had high sensitivity (82.5%) and specificity (91.2%) at an optimal cut-off.

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Implication

Comparative cross-sectional study finds significant haematological changes in hepatitis B infection, suggesting blood indices help assess disease severity in resource-limited settings.

Cite This Study

Shuaib et al. (2026) studied this question.

synapsesocial.com/papers/6a28fecb6f82f25be989befe https://doi.org/10.1007/s44361-026-00041-5

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Implication

Comparative cross-sectional study finds significant haematological changes in hepatitis B infection, suggesting blood indices help assess disease severity in resource-limited settings.

Haematological alterations and diagnostic performance of blood cell indices in hepatitis B virus infection in Edo-North, Nigeria: a comparative cross-sectional study

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Discussion

Implication

Cite This Study

Haematological alterations and diagnostic performance of blood cell indices in hepatitis B virus infection in Edo-North, Nigeria: a comparative cross-sectional study

Key Points

Discussion

Implication

Cite This Study

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