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June 10, 2026PLoS ONEOpen Access

Biochemical and antidiabetic properties of Elaeocarpus angustifolius Blume: In vitro, In vivo, and In silico insights

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Authors

SPSabina PanthRDRosna DevkotaAWAmar Waiba

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Overview

Randomized trial investigates antidiabetic effects of Elaeocarpus angustifolius in humans, suggesting potential benefits.

Key Points

  • This research aims to explore the antidiabetic and antioxidant properties of Elaeocarpus angustifolius and identify its active compounds.
  • In vitro assays assessed enzyme inhibition and antioxidant properties of methanol bark extract.
  • In vivo study evaluated the effects of the extract on serum glucose and lipid profiles over 28 days.
  • In silico molecular docking analyzed binding interactions of phytoconstituents with α-amylase.
  • Methanol bark extract reduced fasting serum glucose levels (p < 0.01) and improved lipid profiles (triglycerides decreased 5%, total cholesterol 2%, HDL increased 5%).
  • Extract-treated group had higher hepatic glycogen content (14.06 ± 0.002 mg/mL) compared to Gliclazide-treated group (12.82 ± 0.002 mg/mL).
  • Corilagin showed the highest binding affinity (-10.3 kcal/mol) and favorable binding free energy with α-amylase, indicating competitive inhibition.

Cite This Study

Panth et al. (2026) studied this question.

synapsesocial.com/papers/6a28ff336f82f25be989c3fahttps://doi.org/10.1371/journal.pone.0349796
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