Ruthenium hydride catalyzed α-alkylation of ketones with primary alcohols for access to bioactive molecules using the borrowing hydrogen approach

Ovender Singh; Youngsuk Kim; Rahul Chauhan; Junseong Lee; Nidhi Tyagi

doi:10.1039/d5cy01446h

January 1, 2026Catalysis Science & Technology

Ruthenium hydride catalyzed α-alkylation of ketones with primary alcohols for access to bioactive molecules using the borrowing hydrogen approach

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Key Points

The aim is to develop a ruthenium hydride catalyst for the α-alkylation of ketones using primary alcohols.
Synthesized a new ruthenium hydride complex [L1RuH(CO)(PPh3)2] featuring a specific ligand.
Characterized the catalyst using various spectroscopy techniques including UV-visible, infrared, NMR, and HRMS.
Confirmed the molecular structure of the ligand and catalyst.
Successfully created the ruthenium hydride complex with high purity and stability.
Demonstrated the compound's effectiveness in catalyzing α-alkylation reactions.
Findings support the adaptability of the borrowing hydrogen approach in synthesizing bioactive molecules.

Implication

Demonstrates effective alkylation of ketones in bioactive molecule synthesis, suggesting important advances in catalysis.

Abstract

A new ruthenium hydride complex, [L1RuH(CO)(PPh3)2] (1), featuring the 2-(2H-benzo[d][1,2,3]triazol-2-yl)-4,6-di-tert-pentylphenol (L1) ligand, has been synthesized and thoroughly characterized by UV-visible, infrared, NMR, and HRMS spectroscopy. The molecular structure was confirmed...

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Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/6a28fff36f82f25be989cbf4 https://doi.org/10.1039/d5cy01446h

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Ruthenium hydride catalyzed α-alkylation of ketones with primary alcohols for access to bioactive molecules using the borrowing hydrogen approach

Key Points

Implication

Abstract

Discussion

Cite This Study

Ruthenium hydride catalyzed α-alkylation of ketones with primary alcohols for access to bioactive molecules using the borrowing hydrogen approach

Key Points

Implication

Abstract

Discussion

Cite This Study

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