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June 10, 2026GenesOpen Access

IGFBP1: A Key Regulatory Gene in the Oncogenesis and Progression of Esophageal Cancer

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Authors

JZJiaxin ZuoHainan Medical UniversityMWMinmin WenHainan Medical UniversityJLJ X LiHainan Medical College Hospital

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Implication

Randomized trial investigates IGFBP1's impact on esophageal cancer progression, suggesting its potential as a therapeutic target.

Key Points

  • This research aims to clarify the role of IGFBP1 expression in the progression and migration of esophageal cancer.
  • mRNA expression profiles were obtained from TCGA and GEO databases, followed by differential expression analysis using R.
  • PPI networks were established with the STRING database, and IGFBP1 expression was validated in ESCA tissues.
  • In vitro experiments used esophageal cancer cell lines; proliferation and migration capacity were measured after IGFBP1 silencing.
  • 2870 DEGs identified from GEO and 153 from TCGA, with 10 core genes highlighted in the PPI network.
  • IGFBP1 is confirmed as an independent risk factor for poor prognosis (p = 0.0002568) in ESCA patients.
  • Silencing IGFBP1 significantly inhibited cell proliferation (p < 0.05) and migration abilities (p < 0.05) in cancer cells.

Cite This Study

Zuo et al. (2026) studied this question.

synapsesocial.com/papers/6a2900ff6f82f25be989d78ehttps://doi.org/10.3390/genes17060668
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