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June 10, 2026RMD OpenOpen Access

Role of the S1P/S1PR axis in inflammation and structural damage in psoriatic arthritis: a cross-sectional study with clinical, biochemical and imaging correlation

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Authors

DRDolores Ruiz-MontesinosDMDolores Mendoza-MendozaJNJ Bocio Nuñez

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Overview

Cross-sectional study finds S1P/S1PR axis is linked to inflammation and damage in psoriatic arthritis, suggesting new treatment targets.

Key Points

  • This study evaluates the role of the S1P/S1PR axis in inflammation and structural damage in psoriatic arthritis (PsA).
  • Cross-sectional observational study with 64 subjects: 21 healthy controls and 43 PsA patients;
  • Clinical activity measured using DAPSA, Doppler ultrasound, MRI, and ELISA for S1P and S1PR levels;
  • Comparison of serum levels and imaging findings between PsA patients and controls. Descriptive analyses were conducted.
  • S1P levels were higher in PsA patients (p=0.013), especially in established PsA (p=0.009);
  • S1PR levels correlated with ultrasound-detected Achilles enthesitis (p=0.046) and bone damage (p=0.03);
  • Patients with established PsA had higher cortical volumetric BMD compared to controls (p=0.027).

Cite This Study

Ruiz-Montesinos et al. (2026) studied this question.

synapsesocial.com/papers/6a29012e6f82f25be989d9abhttps://doi.org/10.1136/rmdopen-2026-006874
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