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October 5, 2025Health Sciences QuarterlyOpen Access

The association of serum S100A8-A9 levels with disease activity, radiological findings and laboratory parameters in patients with psoriatic arthritis

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Authors

BABurcu AvşarTSTuba Erdem SultanoğluŞCŞengül Cangür

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Overview

Observational analysis shows associations with disease activity in psoriatic arthritis patients, highlighting potential biomarkers.

Key Points

  • Higher levels of serum s100a9 correlate with increased disease activity and swollen joint counts in psoriatic arthritis patients.
  • Statistically significant differences were observed, with lower s100a8 levels in psoriasis patients compared to psoriatic arthritis and controls.
  • S100A9 has potential as a biomarker for monitoring disease activity in psoriatic arthritis, despite limitations in routine diagnostics.
  • No significant correlations were found between s100a8-s100a9 levels and inflammatory markers like CRP and ESR.

Cite This Study

Avşar et al. (2025) studied this question.

synapsesocial.com/papers/68e25559d6d66a53c2475104https://doi.org/10.26900/hsq.2803
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeted proteomics reveals serum amyloid A variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis2019 · 31 citations
  2. 2Calprotectin (S100A8/A9) is not associated with ultrasound-detected synovitis in a longitudinal study of patients with psoriatic arthritis treated with biological disease-modifying anti-rheumatic drugs.2025 · 1 citations
  3. 3Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis2024 · 2 citations
  4. 4Role of the S1P/S1PR axis in inflammation and structural damage in psoriatic arthritis: a cross-sectional study with clinical, biochemical and imaging correlation2026
  5. 5POS0780 ASSESSING THE ROLE OF SERUM S100A8/A9 IN EVALUATING ACTIVITY AND CLINICALLY MONITORING OF PATIENTS WITH IGA VASCULITIS2024