Key result
Fully remitted major depressive disorder showed no differences in heart rate variability versus controls, except for decreased cardiac vagal control in those with a history of suicidal ideation.
Why the study?
Does fully remitted major depressive disorder alter heart rate variability compared to healthy volunteers?
Case-Control (n=932)
Does fully remitted major depressive disorder alter heart rate variability compared to healthy volunteers?
Cardiac autonomic dysregulation is not present in fully remitted MDD patients overall, but is observed in the specific subgroup with a history of suicidal ideation.
No routine HRV monitoring indicated in remitted MDD; leaves open targeted vagal assessment in suicidal ideation subgroups.
OBJECTIVE: Cardiac autonomic dysregulation has been reported in major depressive disorder (MDD), but scarce studies investigated that in fully remitted MDD. METHODS: To examine cardiac autonomic function in remitted MDD, 470 unmedicated individuals with a diagnosis of MDD earlier in life and 462 healthy volunteers, aged 18-65 years, were recruited for a case-control analysis. Cardiac autonomic function was evaluated by measuring heart rate variability (HRV) parameters. Frequency-domain indices of HRV were obtained. The obtained results were evaluated in association with personality traits assessed by the Tridimensional Personality Questionnaire. RESULTS: In patients with remitted MDD, no differences in RR intervals and all frequency-domain indices of HRV could be detected as compared with controls. Stratified analyses by the presence of a history of suicide ideation (the SI+ vs. the SI-subgroup) revealed decreased cardiac vagal control in the SI+ subgroup. The correlation analysis revealed an inverse relation between HRV levels and the harm avoidance score (which has been suggested to be associated with serotonergic activity), mainly attributable to the robust association in the SI+ subgroup. CONCLUSION: Our study shows that cardiac autonomic dysregulation is not shown in remitted MDD patients as a whole but is limited to the subgroup of remitted MDD patients with a history of suicidal ideation. In view of the higher risk for cardiac complications in these vulnerable individuals, one might consider the treatment to restore their autonomic function.
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Chang et al. (2012) conducted a case-control in Fully remitted major depressive disorder (n=932). Fully remitted major depressive disorder vs. Healthy volunteers was evaluated on Heart rate variability (HRV) parameters. Fully remitted major depressive disorder showed no differences in heart rate variability versus controls, except for decreased cardiac vagal control in those with a history of suicidal ideation.
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