Key result
Concomitant epicardial left atrial appendage ligation and left atrial ablation achieved stable sinus rhythm in 78% of patients at 12 months, demonstrating feasibility with an acceptable safety profile.
Why the study?
Does concomitant epicardial LAA ligation and left atrial ablation improve rhythm outcomes and safety in patients with persistent AF?
Observational (n=9)
No
Does concomitant epicardial LAA ligation and left atrial ablation improve rhythm outcomes and safety in patients with persistent AF?
Concomitant epicardial LAA ligation and left atrial ablation is feasible in selected patients with persistent AF, resulting in 78% sinus rhythm at 12 months, though safety requires further validation.
May support combined epicardial LAA ligation and ablation in persistent AF; leaves open need for randomized data on outcomes and safety.
INTRODUCTION: We present initial results of patients undergoing a combined procedure of epicardial LAA ligation in addition to left atrial ablation for AF. METHODS: 9 patients were included for additional use of LARIAT as an individual treatment approach for AF. First an epicardial LAA ligation was performed, in the same procedure left atrial ablations consisting of PVI and additional substrate based modifying ablations were performed. Follow-up at 3 months and 12 months was performed. RESULTS: There was only 1 minor procedural complication (11%) involving epicardial bleeding and 2 late adverse events of pericardial tamponade and stroke. At the final follow-up (median 20 months) 7 patients were in stable sinus rhythm (78%) and 2 pts had reduced AF burden. CONCLUSION: Concomitant epicardial LAA ligation and ablation is feasible in selected patients with a reasonable risk profile. More prospective data are required to validate the safety and efficacy.
No takes yet. Share an insight, caveat, or question.
Nentwich et al. (2021) conducted an observational in Persistent atrial fibrillation (n=9). Concomitant epicardial LAA ligation and left atrial ablation was evaluated on Stable sinus rhythm at 12 months. Concomitant epicardial left atrial appendage ligation and left atrial ablation achieved stable sinus rhythm in 78% of patients at 12 months, demonstrating feasibility with an acceptable safety profile.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: