Key result
Oxidative stress associated with a deficit in the antioxidant defense system is proposed to play a critical role in subcellular remodeling, calcium-handling abnormalities, and diabetic cardiomyopathy.
Why the study?
Do pharmacological interventions prevent subcellular remodeling and cardiac dysfunction in chronic diabetes?
Population
Chronic diabetes with heart dysfunction (diabetic cardiomyopathy)
Design
Review
Authors
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Oxidative stress targeting merits investigation in diabetic cardiomyopathy; leaves open whether antioxidants improve outcomes in clinical trials.
Do pharmacological interventions prevent subcellular remodeling and cardiac dysfunction in chronic diabetes?
This review highlights the critical role of oxidative stress and subcellular remodeling in the pathogenesis of diabetic cardiomyopathy and discusses potential pharmacological interventions.
Naranjan S. Dhalla (1998) conducted a review in Chronic diabetes and heart dysfunction. Oxidative stress associated with a deficit in the antioxidant defense system is proposed to play a critical role in subcellular remodeling, calcium-handling abnormalities, and diabetic cardiomyopathy.
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