What is the clinical evidence from this study?

Study design: RCT. Population: Healthy (n=6). Intervention: High inorganic phosphorus meal vs. High organic phosphorus meal (1,200 mg organic P). Primary outcome: Rate of change in flow-mediated dilation (%FMD) at 30 minutes postprandial (p=0.024).

January 1, 2018Journal of Clinical Biochemistry and NutritionOpen Access

Dietary intake of inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus

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Key result

A high inorganic phosphorus meal significantly reduced endothelium-dependent vasodilation at 30 minutes postprandial compared to a high organic phosphorus meal (-20.0% vs -10.1%, p=0.024).

Why the study?

Does a high inorganic phosphorus meal reduce vascular-endothelium function compared to a high organic phosphorus meal in healthy young men?

Population

6 healthy young men without hypertony, smoking history, present illness, or prescription history of…

Comparison

High inorganic phosphorus meal containing 1,000… vs High organic phosphorus meal containing 1,200 mg…

Design

RCT, Randomized, crossover design on two different days separated by at least…

Follow-up

120 minutes postprandial

Authors

HKHiromi Kawamura STSarasa Tanaka YOYuri Ota

Discussion

Member takes

Overview

Inorganic phosphorus additives acutely impair endothelial function more than organic sources; extends evidence distinguishing phosphorus forms in vascular nutrition.

Study Design

Type

RCT (n=6)

Blinding

Double-blind

Randomization

Randomized crossover

Multicenter

Structured PICO

Does a high inorganic phosphorus meal reduce vascular-endothelium function compared to a high organic phosphorus meal in healthy young men?

Population

6 healthy young men without hypertension or smoking history underwent a crossover food intake test to evaluate the acute effects of high inorganic versus organic phosphorus meals over 120 minutes.

Intervention

High inorganic phosphorus meal containing 1,000 mg inorganic phosphorus from food additives and 199.7 mg organic phosphorus from natural food sources (total ~1,200 mg P, ~860 kcal), consumed once.

Comparator

High organic phosphorus meal containing 1,200 mg organic phosphorus from natural food sources (~860 kcal), consumed once in a crossover design.

Outcome

Endothelium-dependent vasodilation measured by flow-mediated dilation (%FMD) from preprandial to 120 minutes postprandial.surrogate

Main Result

Absolute Event Rate: -20% vs -10.1%

p-value: p=0.024

Dietary intake of inorganic phosphorus from food additives acutely impairs vascular endothelial function more severely than an equivalent amount of organic phosphorus from natural foods.

Limitations

Very small sample size (n=6)
Study population limited to healthy young men, limiting generalizability
Only evaluated temporary/acute alteration of phosphate metabolism
Few subjects (n=6)
Subjects were healthy young men, limiting generalizability to other populations such as CKD patients

Cite This Study

Kawamura et al. (2018) conducted an RCT in Healthy (n=6). High inorganic phosphorus meal vs. High organic phosphorus meal (1,200 mg organic P) was evaluated on Rate of change in flow-mediated dilation (%FMD) at 30 minutes postprandial (p=0.024). A high inorganic phosphorus meal significantly reduced endothelium-dependent vasodilation at 30 minutes postprandial compared to a high organic phosphorus meal (-20.0% vs -10.1%, p=0.024).

synapsesocial.com/papers/6a29976b235738631fd2da82 https://doi.org/10.3164/jcbn.17-97

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January 1, 2018Journal of Clinical Biochemistry and NutritionOpen Access

Dietary intake of inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus

View Full Paper

Ask AI

Bookmark

Key result

A high inorganic phosphorus meal significantly reduced endothelium-dependent vasodilation at 30 minutes postprandial compared to a high organic phosphorus meal (-20.0% vs -10.1%, p=0.024).

Why the study?

Does a high inorganic phosphorus meal reduce vascular-endothelium function compared to a high organic phosphorus meal in healthy young men?

Population

6 healthy young men without hypertony, smoking history, present illness, or prescription history of…

Comparison

High inorganic phosphorus meal containing 1,000… vs High organic phosphorus meal containing 1,200 mg…

Design

RCT, Randomized, crossover design on two different days separated by at least…

Follow-up

120 minutes postprandial

Authors

HKHiromi Kawamura STSarasa Tanaka YOYuri Ota

Discussion

Member takes

Overview

Inorganic phosphorus additives acutely impair endothelial function more than organic sources; extends evidence distinguishing phosphorus forms in vascular nutrition.

Study Design

Type

RCT (n=6)

Blinding

Double-blind

Randomization

Randomized crossover

Multicenter

Structured PICO

Does a high inorganic phosphorus meal reduce vascular-endothelium function compared to a high organic phosphorus meal in healthy young men?

Population

6 healthy young men without hypertension or smoking history underwent a crossover food intake test to evaluate the acute effects of high inorganic versus organic phosphorus meals over 120 minutes.

Intervention

High inorganic phosphorus meal containing 1,000 mg inorganic phosphorus from food additives and 199.7 mg organic phosphorus from natural food sources (total ~1,200 mg P, ~860 kcal), consumed once.

Comparator

High organic phosphorus meal containing 1,200 mg organic phosphorus from natural food sources (~860 kcal), consumed once in a crossover design.

Outcome

Endothelium-dependent vasodilation measured by flow-mediated dilation (%FMD) from preprandial to 120 minutes postprandial.surrogate

Main Result

Absolute Event Rate: -20% vs -10.1%

p-value: p=0.024

Dietary intake of inorganic phosphorus from food additives acutely impairs vascular endothelial function more severely than an equivalent amount of organic phosphorus from natural foods.

Limitations

Very small sample size (n=6)
Study population limited to healthy young men, limiting generalizability
Only evaluated temporary/acute alteration of phosphate metabolism
Few subjects (n=6)
Subjects were healthy young men, limiting generalizability to other populations such as CKD patients

Cite This Study

synapsesocial.com/papers/6a29976b235738631fd2da82 https://doi.org/10.3164/jcbn.17-97

Also Consider

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