Key result
Repetitive fluctuations of plasma phosphorus caused by alternating dietary phosphorus intake significantly impaired endothelium-dependent vasodilation and increased oxidative stress compared to a constant phosphorus diet.
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Fluctuating dietary phosphorus may impair endothelial function; hypothesis-generating for CV risk in CKD.
p-value: p=<0.005
Watari et al. (2014) studied Healthy (Animal Model) (n=22). Fluctuating dietary phosphorus intake vs. Constant 0.6% P diet was evaluated on Endothelium-dependent vasodilation (acetylcholine-induced vasorelaxation) (p=<0.005). Repetitive fluctuations of plasma phosphorus caused by alternating dietary phosphorus intake significantly impaired endothelium-dependent vasodilation and increased oxidative stress compared to a constant phosphorus diet.
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