Key result
Somatic mutations in the beta-catenin gene were found in 15% of sporadic adrenocortical adenomas, but not in carcinomas or hyperplasias.
Observational (n=53)
Absolute Event Rate: 15% vs 0%
Activating mutations of exon 3 of the beta-catenin gene are frequent in adrenocortical adenomas, implicating the Wnt/beta-catenin signaling pathway in adrenal tumorigenesis.
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Does not yet alter adrenal tumor management; leaves open Wnt/beta-catenin role in adenoma pathogenesis.
Tadjine et al. (2007) conducted an observational in Adrenocortical tumours and hyperplasias (n=53). beta-catenin gene mutations vs. No mutations was evaluated on Somatic mutations in exons 3 and 5 of the beta-catenin gene. Somatic mutations in the beta-catenin gene were found in 15% of sporadic adrenocortical adenomas, but not in carcinomas or hyperplasias.
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