Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 14, 2016Aging CellOpen Access

CYP 2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK α2 and enhancing nuclear translocation of Akt1

View Full Paper
Ask AI
Bookmark
Share

Key result

Overexpression of CYP2J2 and its metabolites suppressed cardiac hypertrophy and increased ANP levels in wild-type mice but not AMPKα2(-/-) mice by enhancing Akt1 nuclear translocation.

Why the study?

Does CYP2J2 overexpression and its metabolites (EETs) attenuate cardiac hypertrophy in mice?

Population

AMPKα2(-/-) mice and wild-type mice treated with Ang II

Comparison

Overexpression of CYP2J2 in heart and/or… vs Wild-type mice without CYP2J2 overexpression or…

Design

Preclinical

Follow-up

2 weeks

Authors

BWBei WangHZHesong ZengWZWen Zheng

Discussion

Loading...

Member takes

Overview

Hypothesis-generating in mice; leaves open translation of CYP2J2-EETs effects via AMPK-Akt to human hypertrophy.

Structured PICO

Does CYP2J2 overexpression and its metabolites (EETs) attenuate cardiac hypertrophy in mice?

P
Population
AMPKα2(-/-) and wild-type mice treated with Ang II for 2 weeks to study cardiac hypertrophy.
I
Intervention
Overexpression of CYP2J2 in heart and/or treatment with 11,12-EET
C
Comparator
Wild-type mice without CYP2J2 overexpression or AMPKα2(-/-) mice
O
Outcome
Cardiac hypertrophy and atrial natriuretic peptide (ANP) levelssurrogate

CYP2J2 and its metabolites protect against cardiac hypertrophy by enhancing Akt1 nuclear translocation through interaction with AMPKα2β2γ1.

Cite This Study

Wang et al. (2016) studied Cardiac hypertrophy. Overexpression of CYP2J2 and 11,12-EET vs. Wild-type mice without overexpression / AMPKα2(-/-) mice was evaluated on Cardiac hypertrophy and levels of atrial natriuretic peptide (ANP). Overexpression of CYP2J2 and its metabolites suppressed cardiac hypertrophy and increased ANP levels in wild-type mice but not AMPKα2(-/-) mice by enhancing Akt1 nuclear translocation.

synapsesocial.com/papers/6a2a4117c2d5646402a0b9behttps://doi.org/10.1111/acel.12507
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα12/132017 · 29 citations
  2. 2CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy2013 · 62 citations
  3. 3Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II2015 · 67 citations
  4. 4CYP2J2-derived epoxyeicosatrienoic acids protect against doxorubicin-induced cardiotoxicity by reducing oxidative stress and apoptosis via activation of the AMPK pathway2023 · 5 citations
  5. 5Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K + Channels and p42/p44 MAPK Pathway2004 · 272 citations