Key result
Dialyzing at 0.5°C below core body temperature provided complete protection against brain white matter changes at 1 year compared to standard 37°C dialysate.
Why the study?
Does cooled dialysate prevent brain white matter injury in patients on incident hemodialysis?
Population
73 patients on incident hemodialysis starting within 6 months
Comparison
Cooled dialysate for 1 year vs Standard dialysate temperature of 37°C for 1 year
Design
RCT, randomized
Follow-up
1 year
Authors
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Cooled dialysate may be adopted in incident hemodialysis to avert ischemic brain injury; extends hemodynamic benefits to 1-year neuroimaging protection in this RCT.
RCT (n=73)
randomized
Does cooled dialysate prevent brain white matter injury in patients on incident hemodialysis?
Using cooled dialysate (0.5°C below core body temperature) during hemodialysis improves hemodynamic tolerability and protects against ischemic brain white matter injury.
Eldehni et al. (2014) conducted an RCT in Incident hemodialysis (n=73). Cooled dialysate vs. 37°C dialysate temperature was evaluated on Brain white matter microstructure changes. Dialyzing at 0.5°C below core body temperature provided complete protection against brain white matter changes at 1 year compared to standard 37°C dialysate.
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