Key result
Individualized dialysate cooling did not alter left ventricular ejection fraction (difference 1.5%; 95% CI -4.3 to 7.3) but slowed the progression of hemodialysis-associated cardiomyopathy.
Why the study?
Does individualized dialysate cooling improve left ventricular ejection fraction in incident hemodialysis patients?
Population
73 incident hemodialysis (HD) patients
Comparison
Individualized dialysate cooling at 0.5°C below… vs Dialysate temperature of 37°C for 12 months
Design
RCT, randomly assigned
Follow-up
12 months
Authors
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Cooled dialysate may limit recurrent HD injury; leaves open whether it yields long-term cardiac structural or functional benefits in larger cohorts.
RCT (n=73)
Randomly assigned
Does individualized dialysate cooling improve left ventricular ejection fraction in incident hemodialysis patients?
Mean Difference: 1.5 (95% CI -4.3–7.3)
In incident hemodialysis patients, individualized dialysate cooling did not alter LVEF but preserved left ventricular strain and reduced LV mass and dilation.
Odudu et al. (2015) conducted an RCT in Hemodialysis (n=73). Individualized dialysate cooling vs. Dialysate temperature of 37°C was evaluated on Left ventricular ejection fraction (MD 1.5%, 95% CI -4.3 to 7.3). Individualized dialysate cooling did not alter left ventricular ejection fraction (difference 1.5%; 95% CI -4.3 to 7.3) but slowed the progression of hemodialysis-associated cardiomyopathy.
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