Why the study?
Diabetic cardiomyopathy occurs independently of cardiovascular disease or hypertension, leading to heart failure, but the underlying molecular mechanisms remain to be investigated.
Population
Six-month-old C57BL/6J-lepr/lepr (db/db) mice
Design
Preclinical quantitative proteomic profiling study
Authors
Loading...
Impaired maximal respiration in diabetic mouse hearts; hypothesis-generating for mitochondrial energy targets in diabetic cardiomyopathy.
Proteomic analysis of diabetic mice hearts reveals altered mitochondrial metabolic profiles, suggesting that decreased levels of key electron transport chain components contribute to impaired ATP production and cardiac dysfunction in diabetic cardiomyopathy.
Gomes et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: