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September 21, 2015Journal of Biochemical and Molecular Toxicology

Thymol and Carvacrol Prevent Doxorubicin‐Induced Cardiotoxicity by Abrogation of Oxidative Stress, Inflammation, and Apoptosis in Rats

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Key result

Administration of thymol and carvacrol ameliorated doxorubicin-induced cardiotoxicity and oxidative stress in male rats, with their combination showing a synergistic cardioprotective effect.

Authors

EEEl‐Sayed El‐SayedAMAhmed M. MansourMAMohammed S. Abdul‐Hameed

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Overview

May support preclinical testing of thymol-carvacrol combinations against doxorubicin cardiotoxicity; hypothesis-generating and should not yet change practice.

PICO

P
Population
Male rats subjected to doxorubicin-induced cardiotoxicity.
I
Intervention / Comparator
Thymol and/or carvacrol vs Control group (doxorubicin alone) (Thymol 20 mg/kg p.o. and/or carvacrol 25 mg/kg p.o.)
O
Primary Outcome
Cardiotoxicity markers (serum LDH, CK, CK-MB, AST, TNF-alpha, cardiac troponin, heart MDA, caspase-3, GSH, catalase, SOD)

Cite This Study

El‐Sayed et al. (2015) studied Doxorubicin-induced cardiotoxicity. Thymol and/or carvacrol vs. Control group (doxorubicin alone) was evaluated on Cardiotoxicity markers (serum LDH, CK, CK-MB, AST, TNF-alpha, cardiac troponin, heart MDA, caspase-3, GSH, catalase, SOD). Administration of thymol and carvacrol ameliorated doxorubicin-induced cardiotoxicity and oxidative stress in male rats, with their combination showing a synergistic cardioprotective effect.

synapsesocial.com/papers/6a2a5075a94d6bc7baa23488https://doi.org/10.1002/jbt.21740
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