Key result
Administration of carotenoids prevented doxorubicin-induced depletion of antioxidants and tissue damage in the heart and liver of tumor-bearing mice without altering tumor tissue architecture.
Why the study?
Do carotenoids prevent doxorubicin-induced acute cardiotoxicity and hepatotoxicity in tumor-bearing mice?
Do carotenoids prevent doxorubicin-induced acute cardiotoxicity and hepatotoxicity in tumor-bearing mice?
Carotenoids may offer a protective effect against doxorubicin-induced acute cardiotoxicity and hepatotoxicity without compromising anti-tumor efficacy in preclinical models.
Answers are grounded in this paper and cite their sources.
May support further preclinical testing of carotenoids against doxorubicin toxicity; leaves open human translation.
AIM OF STUDY: The aim of this study is to explore the ability of the carotenoids (CARs) to offer protection against acute cardiotoxicity and hepatotoxicity induced by doxorubicin (DOX) (25 mg/kg) in tumor bearing Swiss albino mice. MATERIALS AND METHODS: Tumor bearing Swiss albino mice administered with DOX (25 mg/kg, i.p) and two doses of CARs (50 and 100 μg/kg). 24 h after administration of the drugs, histopathological evaluation of tumor, liver and heart tissues carried out. Furthermore, various antioxidant parameters in these tissues were investigated. Serum marker enzymes for tissue injury were examined. RESULTS: Administration of CARs prevented the depletion of antioxidants in the heart and liver, thereby protecting the tissue damage and release of marker enzymes. However, similar antioxidant depletion was not observed in the tumor tissue. CARs prevented DOX induced variation in tissue architecture in heart and liver tissues. However, CARs did not influence DOX induced alterations in the tumor. CONCLUSION: Administration of CARs could prevent DOX induced acute toxicity to heart and liver.
No takes yet. Share an insight, caveat, or question.
Nair et al. (2014) studied Doxorubicin-induced cardio- and hepatotoxicity. Carotenoids vs. Doxorubicin alone was evaluated on Histopathological evaluation of tumor, liver and heart tissues, antioxidant parameters, and serum marker enzymes. Administration of carotenoids prevented doxorubicin-induced depletion of antioxidants and tissue damage in the heart and liver of tumor-bearing mice without altering tumor tissue architecture.
Synapse has enriched 10 related papers. Consider them for comparative context: