Key result
Administration of carotenoids prevented doxorubicin-induced depletion of antioxidants and tissue damage in the heart and liver of tumor-bearing mice without altering tumor tissue architecture.
Why the study?
Do carotenoids prevent doxorubicin-induced acute cardiotoxicity and hepatotoxicity in tumor-bearing mice?
Population
Tumor bearing Swiss albino mice
Design
Preclinical
Follow-up
24 h
Authors
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May support further preclinical testing of carotenoids against doxorubicin toxicity; leaves open human translation.
Do carotenoids prevent doxorubicin-induced acute cardiotoxicity and hepatotoxicity in tumor-bearing mice?
Carotenoids may offer a protective effect against doxorubicin-induced acute cardiotoxicity and hepatotoxicity without compromising anti-tumor efficacy in preclinical models.
Nair et al. (2014) studied Doxorubicin-induced cardio- and hepatotoxicity. Carotenoids vs. Doxorubicin alone was evaluated on Histopathological evaluation of tumor, liver and heart tissues, antioxidant parameters, and serum marker enzymes. Administration of carotenoids prevented doxorubicin-induced depletion of antioxidants and tissue damage in the heart and liver of tumor-bearing mice without altering tumor tissue architecture.
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