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June 11, 2026Journal of Taibah University Medical SciencesOpen Access

Effects of cleaning agents and Candida Biofilms on dental resin integrity

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Authors

MUMuhammad Khawaja Hammad UddinAKAnam KhanZMZulfiqar A. Mirani

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Overview

Randomized trial examines impact of cleaning agents on dental resin, suggesting material-specific protocols are needed.

Key Points

  • This research investigates how cleaning agents and Candida albicans biofilms affect the integrity of dental resins.
  • Fabricated 240 specimens of PMMA and nano-filled composite resin.
  • Evaluated baseline hardness, surface roughness, and flexural strength.
  • Subjected specimens to 90-day biofilm challenge and treated with sodium hypochlorite or patchouli extract.
  • Nano-filled composite showed greater baseline hardness (156.67 ± 0.58 VHN) compared to PMMA (98.60 ± 0.55 VHN; p < 0.001).
  • NaOCl exposure resulted in a 36.13% loss of PMMA flexural strength (p < 0.001), while patchouli extract showed no significant degradation (p > 0.05).
  • Both agents had limited efficacy against mature biofilms, despite NaOCl being effective against planktonic C. albicans.

Cite This Study

Uddin et al. (2026) studied this question.

synapsesocial.com/papers/6a2a50e080c8f91e7f39d425https://doi.org/10.1016/j.jtumed.2026.05.003
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  5. 5Surface properties and biofilm formation of a manufacturer-reinforced, nanographene-modified pre-polymerized CAD-CAM polymethylmethacrylate denture base material: An in vitro study.2026