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June 11, 2026Chinese Medical Journal - Pulmonary and Critical Care MedicineOpen Access

Molecular mechanisms and therapeutic targets in lung cancer–nerve crosstalk

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Authors

ZXZiyang XuSHShanshan HuangQCQian Chu

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Overview

Review highlights the role of nerve interactions in lung cancer, suggesting avenues for neuro-modulatory therapies.

Key Points

  • This review investigates the role of nerve interactions in lung cancer progression and metastasis, aiming to identify therapeutic targets.
  • Synthesis of existing evidence on lung cancer and nerve interactions.
  • Focus on neural remodeling, tumor microenvironment, and the neuro-immune axis.
  • Discussion on translational opportunities for neuro-modulatory interventions.
  • Neuronal activity influences lung tumor growth and metastasis through paracrine signaling.
  • β-adrenergic blockade linked to reduced lung tumor growth and metastasis.
  • Provides a framework for future studies on neuro-modulation in lung cancer.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a2a50e080c8f91e7f39d551https://doi.org/10.1016/j.pccm.2026.05.003
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