What is the clinical evidence from this study?

Study design: Review. Population: Virus-related cardiac diseases. Intervention: Viral infections (including SARS-CoV-2, influenza, HIV, enteroviruses, HCMV, arboviruses).

What does this research mean for the field?

Viral infections contribute to diverse cardiovascular pathologies through direct cytopathic infection and indirect immune-mediated injury, requiring integrated prevention, acute antiviral/immunomodulatory management, and long-term care. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Synthesize current evidence on the pathophysiological mechanisms, clinical manifestations, and management strategies of virus-induced cardiovascular diseases.

June 11, 2026Journal of VirologyOpen Access

Research progress on the association between viruses and cardiac diseases

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Key result

Cardiotropic and cardioactive viruses trigger myocarditis, arrhythmias, and heart failure via direct and immune-mediated injury.

Key Points

Synthesize current evidence on the pathophysiological mechanisms, clinical manifestations, and management strategies of virus-induced cardiovascular diseases.
Synthesized mechanistic and clinical evidence across major cardiotropic viruses, including SARS-CoV-2, influenza virus, HIV, enteroviruses, and arboviruses.
Evaluated direct viral cytopathic effects, immune-mediated myocardial damage, and systemic vascular complications such as endothelial dysfunction and thrombosis.
Cardiotropic viruses trigger myocardial injury, heart failure, and arrhythmias via direct cellular infection (e.g., spike protein binding to ACE2) and secondary inflammatory cascades.
Systemic viral consequences promote endothelial dysfunction and prothrombotic states, increasing the incidence of acute myocardial infarction and stroke.
Optimal disease management requires early antiviral administration, tailored immunomodulation avoiding broad immunosuppression, and prevention via vaccination and vector control.

PICO

Population

Virus-related cardiac diseases

Exposure / Comparator

Viral infections (including SARS-CoV-2, influenza, HIV, enteroviruses, HCMV, arboviruses)

This review synthesizes current evidence on how various viral infections cause cardiovascular diseases through direct and indirect mechanisms, emphasizing the importance of vaccination, early antiviral therapy, and targeted immunomodulation.

Limitations

Diagnostic challenges in confirming direct cardiac infection in human studies
Substantial interindividual variability in the degree of myocardial viral burden and inflammatory injury
Experimental studies for arboviruses often rely on susceptibility-enhanced animal models rather than immunocompetent hosts

Discussion

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Implication

Alerts clinicians to consider viral etiologies in unexplained myocarditis or HF; extends mechanistic data but leaves optimal therapies unresolved.

Cite This Study

He-min et al. (2026) conducted a review in Virus-related cardiac diseases. Viral infections (including SARS-CoV-2, influenza, HIV, enteroviruses, HCMV, arboviruses) was evaluated. Major cardiotropic and cardioactive viruses cause diverse cardiovascular pathologies through direct infection and indirect immune-mediated injury, manifesting as myocarditis, arrhythmias, and heart failure.

synapsesocial.com/papers/6a2a510680c8f91e7f39d74c https://doi.org/10.1128/jvi.00383-26

Topics

Myocarditis Pericardial disease COVID-19 cardiovascular Cardiovascular prevention

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Implication

Alerts clinicians to consider viral etiologies in unexplained myocarditis or HF; extends mechanistic data but leaves optimal therapies unresolved.

Research progress on the association between viruses and cardiac diseases

Key Points

PICO

Limitations

Discussion

Implication

Cite This Study

Topics

Research progress on the association between viruses and cardiac diseases

Key Points

PICO

Limitations

Discussion

Implication

Cite This Study

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