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June 11, 2026European Journal of Immunology

Identifying Negative Biomarkers of CD4 Cytotoxic T Lymphocytes via Granzyme B Exclusion Analysis

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Authors

BWBo WangABAyibaota BahabayiDHD J Y Huang

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Overview

Randomized trial identifies negative biomarkers of CD4 cytotoxic T lymphocytes, suggesting new diagnostics.

Key Points

  • This study aims to identify negative biomarkers for CD4 cytotoxic T lymphocytes using granzyme B exclusion analysis.
  • Performed gene-plasticity-based mutual exclusion analysis.
  • Analyzed bulk RNA-seq data from 768 human CD4+ T cell samples.
  • Validated selected genes via flow cytometry in healthy individuals and Sjögren's syndrome patients.
  • Identified ITGA6 and IL6R as negative biomarkers, anti-correlated with granzyme B levels.
  • CD49f - CD126 - GPR56 + CD4 + T cells showed the highest GZMB levels.
  • Diagnostic accuracy for GZMB in CD4 + T cells was AUC = 0.766.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a2a512e80c8f91e7f39d786https://doi.org/10.1002/eji.70213
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Also Consider

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  5. 5Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen Receptor T Cell–Mediated Cytotoxicity2024 · 7 citations