What question did this study set out to answer?

Evaluate the radiation dose to healthy breast tissue from an implanted 125I localization seed.

Radioactive Seed Localization for the Resection of Nonpalpable Breast Lesions: A “No Later Than” Date Dosimetric Approach

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Randomized trial evaluates radiation dose to healthy breast tissue during RSL, suggesting safe timing for seed removal.

Evaluate the radiation dose to healthy breast tissue from an implanted 125I localization seed.
Used a simplified hemispherical breast model in MATLAB and a Monte Carlo simulation in Mathematica.
Incorporated dosimetric parameters from AAPM Task Group 43 and tissue properties as per ICRP guidelines.
Analyzed cumulative dose at various distances and implantation times.
Cumulative dose at 1 cm reached approximately 3-4 cGy after 5 days and about 50 cGy after 200 days.
Dose to healthy breast tissue remained below thresholds associated with deterministic effects.
Agreement between MATLAB and Monte Carlo models was within expected limits, indicating reliability of models.

Ward et al. (2026) studied this question.

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