What question did this study set out to answer?

The aim is to design and evaluate a gel formulation using SNEDDS for enhancing topical delivery of meloxicam.

Design and Evaluation of a Self-nanoemulsifying Drug Delivery System-based Meloxicam Gel for Enhanced Topical Delivery

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Randomized trial evaluates a meloxicam gel formulation, suggesting enhanced topical bioavailability for improved delivery.

The aim is to design and evaluate a gel formulation using SNEDDS for enhancing topical delivery of meloxicam.
Screened various excipients for solubility and created ternary phase diagrams to select optimal surfactant ratios.
Characterized the SNEDDS formulations for zeta potential and droplet size, then incorporated them into optimized gels using factorial design.
Evaluated formulation stability and viscosity through a systematic approach.
Optimized SNEDDS formulation (F10) showed mean droplet size of 160.20±2.65 nm and zeta potential of -30 mV±1.24.
G3 formulation demonstrated significant viscosity and a sustained drug release profile, with 93% cumulative drug release in 60 minutes.
Incorporation into gel improved drug content and viscosity, indicating enhanced effectiveness of topical delivery.

Pophale et al. (2026) studied this question.

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