What does this research mean for the field?

Thermosensitive polyurethane hydrogels loaded with meloxicam demonstrate self-healing properties and release 60% to 90% of the active drug depending on the specific excipients used, driven by competing Fickian and chain relaxation mechanisms. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop and evaluate thermosensitive polyurethane hydrogels containing meloxicam, assessing how various excipients and absorption promoters affect rheology, drug release kinetics, and anti-inflammatory activity.

August 27, 2026PolymersOpen Access

Highlighting the Anti-Inflammatory Activity of Topical Gels Loaded with Meloxicam: The Role of Different Excipients and Absorption Promoters

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Authors

IPIoana‐Alexandra PlugariuInstitutul de Chimie Macromoleculară Petru Poni LGLuiza Mădălina GrădinaruAlexandru Ioan Cuza University IPIrina PopescuUniversity of Modena and Reggio Emilia

Discussion

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Implication

In vitro study reveals sustained drug release and anti-inflammatory activity in meloxicam-loaded thermosensitive hydrogels, indicating strong potential for topical pain delivery systems.

Key Points

To develop and evaluate thermosensitive polyurethane hydrogels containing meloxicam, assessing how various excipients and absorption promoters affect rheology, drug release kinetics, and anti-inflammatory activity.
Formulated thermosensitive polyurethane hydrogels loaded with meloxicam alongside excipients including eucalyptus essential oil, poly(vinylpyrrolidone), poly(ethylene glycol), and their mixtures.
Assessed sol–gel transition, network viscoelasticity at 37 °C, structural recovery after high strain, in vitro release kinetics, and in vitro anti-inflammatory performance.
Hydrogels exhibited temperature-triggered sol–gel transitions, robust network stability at 37 °C, and rapid self-healing recovery after mechanical strain.
Formulations achieved 60% to 90% active meloxicam release driven by competing Fickian diffusion and polymer chain relaxation, demonstrating effective in vitro anti-inflammatory activity.

Cite This Study

Plugariu et al. (2026) studied this question.

synapsesocial.com/papers/6a8fea0d10c91c1e926220f7 https://doi.org/10.3390/polym18172065

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Implication

In vitro study reveals sustained drug release and anti-inflammatory activity in meloxicam-loaded thermosensitive hydrogels, indicating strong potential for topical pain delivery systems.

Highlighting the Anti-Inflammatory Activity of Topical Gels Loaded with Meloxicam: The Role of Different Excipients and Absorption Promoters

Discussion

Member takes

Implication

Key Points

Cite This Study

Highlighting the Anti-Inflammatory Activity of Topical Gels Loaded with Meloxicam: The Role of Different Excipients and Absorption Promoters

Discussion

Member takes

Implication

Key Points

Cite This Study

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