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June 11, 2026The Journal of Dermatology

Hypopigmented Mycosis Fungoides With Childhood‐Onset and Middle‐Aged Onset: Two Case Reports Focusing on the Cutaneous Immune Microenvironment

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Authors

YYYoko YahagiTFTaku FujimuraAYArisa Yoshida

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Overview

Case reports reveal distinct immune profiles in hypopigmented mycosis fungoides at different ages, suggesting a shared immune response.

Key Points

  • To characterize the immune microenvironment in hypopigmented mycosis fungoides at varying ages of onset.
  • Reported two cases of hypopigmented mycosis fungoides with different onset ages.
  • Evaluated lesional immune profiles using immunohistochemistry for CD8, FOXP3, CXCL10, and CCL19.
  • Assessed cytotoxic immune responses and T-cell phenotypes in skin lesions.
  • Both cases showed CD8-positive T-cell dominance in the epidermotropic infiltrate.
  • FOXP3-positive cells were scarce, indicating a reduced regulatory T-cell presence.
  • Increased expression of CXCL10 and CCL19 may correlate with hypopigmentation regardless of onset age.

Cite This Study

Yahagi et al. (2026) studied this question.

synapsesocial.com/papers/6a2a517c80c8f91e7f39dbdbhttps://doi.org/10.1111/1346-8138.70343
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond the pale: Insights into hypopigmented mycosis fungoides – A case report2024 · 1 citations
  2. 2Adult-Onset Hypopigmented Mycosis Fungoides: A Systematic Review of Clinicopathologic, Immunophenotypic, and Therapeutic Characteristics2026
  3. 3Early‐Onset Hypopigmented Mycosis Fungoides in a Young Female: Navigating Diagnostic Delays and Treatment Complexities—A Case Report2025
  4. 4Early‐Onset Hypopigmented Mycosis Fungoides in a Young Female: Navigating Diagnostic Delays and Treatment Complexities—A Case Report2025
  5. 5An illustrative case of hypopigmented mycosis fungoides2025 · 2 citations