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January 17, 2026CancersOpen Access

Adult-Onset Hypopigmented Mycosis Fungoides: A Systematic Review of Clinicopathologic, Immunophenotypic, and Therapeutic Characteristics

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Authors

AKAgnieszka KimakUniversity Teaching HospitalEREwa RobakTRTadeusz RobakCopernicus Memorial Hospital

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Implication

Systematic review examines hypopigmented mycosis fungoides characteristics in adults, suggesting PUVA may improve outcomes.

Key Points

  • The review aims to analyze the clinicopathologic and therapeutic features of adult-onset hypopigmented mycosis fungoides.
  • Conducted a systematic review using SCOPUS, PubMed, and Embase databases
  • Included 13 original articles with a total of 34 patients
  • Focused on cases with onset at or after 30 years of age
  • Most cases remained at stage IB throughout treatment
  • PUVA therapy showed higher complete remission rates compared to UVB (13 out of 17 vs. 8 out of 16)
  • Recurrences were less frequent and developed slower in the PUVA group, although some progression occurred in three patients

Cite This Study

Kimak et al. (2026) studied this question.

synapsesocial.com/papers/696b2616d2a12237a934969dhttps://doi.org/10.3390/cancers18020265
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-World Clinical Characteristics, Management, and Outcomes of 44 Paediatric Patients with Hypopigmented Mycosis Fungoides2023 · 6 citations
  2. 2Rapidly Progressing CD8-negative Hypopigmented Mycosis Fungoides in Adult Caucasian Male with Good Response to Mogamulizumab2025 · 1 citations
  3. 3Hypopigmented mycosis fungoides: a retrospective clinicohistopathologic study2016 · 60 citations