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This report aims to highlight the potential role of flumazenil in managing severe bronchospasm following remimazolam-induced hypersensitivity.

Possible bronchospasm relief following flumazenil administration in a remimazolam-induced Grade III hypersensitivity reaction: a case report

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Case report demonstrates flumazenil's potential to alleviate bronchospasm in a severe remimazolam reaction, suggesting further study is needed.

This report aims to highlight the potential role of flumazenil in managing severe bronchospasm following remimazolam-induced hypersensitivity.
Descriptive case report of a 49-year-old female experiencing Grade III hypersensitivity after remimazolam.
Administration of intravenous flumazenil and additional adrenaline after inadequate response to standard treatment.
Assessment of clinical symptoms and hemodynamic stability following intervention.
Initial symptoms included severe bronchospasm, hemodynamic instability, and other allergic manifestations.
Flumazenil administration led to gradual resolution of symptoms and stabilization of blood pressure and oxygen saturation.
No definitive conclusions on flumazenil's therapeutic role can be drawn from a single case report with multiple interventions.

Shu et al. (2026) studied this question.

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Case report demonstrates flumazenil's potential to alleviate bronchospasm in a severe remimazolam reaction, suggesting further study is needed.