Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 11, 2026APL BioengineeringOpen Access

Photobiomodulation outperforms ultrasound in reducing IL-1 β -driven chondrocyte inflammation

View Full Paper
Ask AI
Bookmark
Share

Authors

SOSofia OliveiraDFDébora FerreiraLRL. R. Rodrigues

Discussion

Loading...

Member takes

Overview

Randomized trial finds photobiomodulation enhances cartilage matrix synthesis in chondrocytes, suggesting effective cartilage repair strategies.

Key Points

  • The aim is to evaluate the effects of photobiomodulation and ultrasound on chondrocyte responses to inflammation and cartilage matrix synthesis.
  • Human chondrocytes were cultured with or without 1 ng/ml IL-1β and stimulated with US and PBM for 6 days.
  • Chondrocyte activity and gene expression were analyzed for cartilage synthesis and degradation markers before and after treatment.
  • The effects of sequential combinations of US and PBM were compared against individual treatments.
  • Both US and PBM increased collagen type II and aggrecan expression under all conditions assessed.
  • PBM stimulated GAG synthesis and did not increase cartilage destruction markers, whereas US increased metalloproteinases and IL-1β mRNA levels.
  • Sequential treatment did not surpass the benefits of individual treatments despite showing varied bioeffects.

Cite This Study

Oliveira et al. (2026) studied this question.

synapsesocial.com/papers/6a2a51d780c8f91e7f39dfe4https://doi.org/10.1063/5.0323327
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Near-infrared photobiomodulation stimulates viability and cartilage matrix synthesis in human chondrocytes2025 · 1 citations
  2. 2Photobiomodulation Activates Coordinated Signaling Networks to Modulate Inflammation, Adaptive Stress, and Tissue Healing via Redox-Mediated NFκB–TGF-β1–ATF-4 Axis2026 · 8 citations
  3. 3Synergistic Effects of Therapeutic Ultrasound and Biomaterials in Osteoarthritis2025
  4. 4Comparative Effects of Photobiomodulation and Platelet‐Rich Plasma on Joint Repair in Rats With Knee Osteoarthritis2026
  5. 5Effect of photobiomodulation using red <scp>LED</scp> (630 nm) on the metabolism of human osteoblasts2026