What question did this study set out to answer?

To determine the optimal light-emitting diode photobiomodulation parameters and dosage for enhancing the metabolic activity, proliferation, and extracellular matrix production of human chondrocytes.

December 29, 2025Scientific ReportsOpen Access

Near-infrared photobiomodulation stimulates viability and cartilage matrix synthesis in human chondrocytes

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Authors

SOSofia OliveiraUniversity of Minho DFDébora FerreiraCentro de Computação Gráfica JPJorge PadrãoUniversity of Minho

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Implication

In vitro study demonstrates near-infrared light stimulates viability and matrix synthesis in human chondrocytes, suggesting potential as a non-invasive therapy for cartilage repair.

Key Points

To determine the optimal light-emitting diode photobiomodulation parameters and dosage for enhancing the metabolic activity, proliferation, and extracellular matrix production of human chondrocytes.
Human chondrocytes were stimulated daily or every other day using light-emitting diodes at wavelengths of 600–940 nm and power densities of 4–17 mW/cm² in continuous or pulsed modes for up to 4 minutes.
Protocols showing the highest efficacy after 3 days were applied for 7 days to evaluate cartilage matrix synthesis using immunocytochemistry, western blot, and alcian blue staining alongside temperature monitoring.
Near-infrared wavelengths at 850 and 940 nm significantly increased chondrocyte metabolic activity across power densities of 4–17 mW/cm² in continuous and pulsed modes without causing a significant temperature rise.
Treatment with 940 nm light at 17 mW/cm² consistently stimulated the deposition of collagen type II, aggrecan, and glycosaminoglycans while preserving the native chondrocyte phenotype.

Cite This Study

Oliveira et al. (2025) studied this question.

synapsesocial.com/papers/6a8a60470f137e402b3386c4 https://doi.org/10.1038/s41598-025-28792-y

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Implication

In vitro study demonstrates near-infrared light stimulates viability and matrix synthesis in human chondrocytes, suggesting potential as a non-invasive therapy for cartilage repair.

Near-infrared photobiomodulation stimulates viability and cartilage matrix synthesis in human chondrocytes

Discussion

Member takes

Implication

Key Points

Cite This Study

Near-infrared photobiomodulation stimulates viability and cartilage matrix synthesis in human chondrocytes

Discussion

Member takes

Implication

Key Points

Cite This Study

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