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This study aims to evaluate the effects of photobiomodulation using red LED light on human osteoblast-like cells' metabolism and migration.

Effect of photobiomodulation using red LED (630 nm) on the metabolism of human osteoblasts

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This study aims to evaluate the effects of photobiomodulation using red LED light on human osteoblast-like cells' metabolism and migration.
In vitro study of human osteoblast-like SAOS-2 cells treated with red LED light at fluences of 2, 4, or 6 J/cm².
Cells were compared to a nonirradiated control and assessed for viability, protein production, ALP activity, collagen synthesis, mineralization, and migration over 7 and 14 days.
Irradiation was conducted in three applications spaced 12 hours apart.
At day 14, total protein and collagen synthesis increased, with significantly greater collagen at 6 J/cm².
ALP activity peaked at day 7, with 2 and 6 J/cm² groups showing lower levels than the control.
Migration was highest at 2 J/cm², and higher cell density observed at 6 J/cm².

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In vitro study evaluates photobiomodulation effects on osteoblasts' metabolism and migration, suggesting enhanced bone repair strategies.

Moreira et al. (2026) studied this question.

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