Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 11, 2026Advanced ScienceOpen Access

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

View Full Paper
Ask AI
Bookmark
Share

Authors

CZChang ZhangJLJiayi LuSYSihao Yan

Discussion

Loading...

Member takes

Overview

Randomized trial investigates m7G modification's role in psoriatic inflammation, suggesting new treatment targets.

Key Points

  • This research aims to elucidate the role of METTL1-mediated m7G modifications in driving psoriatic inflammation.
  • Analyzed METTL1 levels in human psoriatic lesions and IMQ-induced murine models.
  • Used Mettl1 fl/fl Krt14-Cre ERT2 mice to assess inflammation and neutrophil recruitment.
  • Explored pharmacological inhibition and genetic overexpression of BDKRB1.
  • Mettl1-deficient mice showed significantly reduced psoriasiform inflammation and decreased neutrophil infiltration.
  • BDKRB1 overexpression rescued inflammatory phenotypes in METTL1-deficient models.
  • Inhibition of the METTL1-BDKRB1 axis mitigated psoriasiform inflammation.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2a520a80c8f91e7f39e21chttps://doi.org/10.1002/advs.75970
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1METTL7A‐Dependent m <sup>6</sup> A Methylation Orchestrates CXCR4 <sup>hi</sup> Neutrophil Pathogenicity and NETosis in Skin Inflammation2026
  2. 2<i>N</i> <sup>6</sup> -methyladenosine modification–tuned lipid metabolism controls skin immune homeostasis via regulating neutrophil chemotaxis2024 · 23 citations
  3. 3METTL1-mediated m <sup>7</sup> G methylation of <i>Sarm1</i> mRNA promotes macrophage inflammatory responses and multiple organ injury2025 · 16 citations
  4. 4Comprehensive Analysis of Crucial m6A-Related Differentially Expressed Genes in Psoriasis2024 · 4 citations
  5. 5Methyltransferase METTL1 regulates MSC mRNA stability via m7G modification in acute pancreatitis2026