Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 20, 2026MedCommOpen Access

METTL7A‐Dependent m 6 A Methylation Orchestrates CXCR4 hi Neutrophil Pathogenicity and NETosis in Skin Inflammation

View Full Paper
Ask AI
Bookmark
Share

Authors

WLWanting LiuXijing HospitalJLJinkai LiangXijing HospitalHQHuiyi QuanXijing Hospital

Discussion

Loading...

Member takes

Implication

Preclinical study reveals that METTL7A drives CXCR4-high neutrophil NETosis via PLSCR1 m6A modification, indicating a potential target for psoriasis.

Key Points

  • To determine the role of the m6A methyltransferase METTL7A in driving CXCR4-high neutrophil activation, NETosis, and skin inflammation in psoriasis.
  • Analyzed transcriptomic profiles and m6A RNA immunoprecipitation in CXCR4-high neutrophils from patients with psoriasis and in differentiating HL-60 cells.
  • Evaluated the functional effects of genetic silencing and adoptive transfer of METTL7A-deficient neutrophils in murine models of psoriasiform skin inflammation.
  • METTL7A expression was preferentially upregulated in aged, pathogenic CXCR4-high neutrophils and correlated positively with psoriasis severity.
  • Silencing METTL7A impaired neutrophil maturation, suppressed reactive oxygen species and NETosis, and attenuated skin inflammation in vivo.
  • METTL7A stabilized PLSCR1 mRNA in an m6A-dependent manner to enhance NET formation and drive inflammatory pathology.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a86b57f8a91293e6a1ccf68https://doi.org/10.1002/mco2.70941
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1N 6 -methyladenosine modification–tuned lipid metabolism controls skin immune homeostasis via regulating neutrophil chemotaxis2024 · 23 citations
  2. 2Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis2020 · 25 citations
  3. 3A Novel Localization of METTL7A in Bergmann Glial Cells in Human Cerebellum2023 · 8 citations
  4. 4METTL3 Inhibition Restores PD-L1 Expression and CD8+ T-cell Cytotoxic Function in Immunotherapy-Treated Gastric Cancer2025 · 26 citations
  5. 5m 6 A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation2015 · 1,644 citations