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This study aims to unravel the role of METTL1 in mRNA stability and its implications in acute pancreatitis.

June 26, 2026Cell Death and DiseaseOpen Access

Methyltransferase METTL1 regulates MSC mRNA stability via m7G modification in acute pancreatitis

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Randomized trial reveals a METTL1-m7G-MSC-TNF signaling axis in acute pancreatitis, suggesting a novel therapeutic target.

This study aims to unravel the role of METTL1 in mRNA stability and its implications in acute pancreatitis.
Identified METTL1 and m7G levels in AP patients and animal models, including sodium taurocholate-induced mice.
Conducted multi-omics analysis combining m7G methylome mapping and transcriptome profiling.
Performed in vivo knockdown of Mettl1 in mouse models to assess AP severity.
Elevated METTL1 and m7G levels were detected in serum of AP patients and pancreatic tissues of mice models.
MSC mRNA stability was enhanced via METTL1-mediated m7G modification, activating TNF signaling pathways.
Mettl1 knockdown significantly reduced the severity of acute pancreatitis.

Tao et al. (2026) studied this question.

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