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June 11, 2026Review Journal of Autism and Developmental DisordersOpen Access

Sex/Gender Differences in Co-occurring Neurodevelopmental and Mental Health Conditions of Autistic Adults: a Systematic Review and Meta-analysis

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Authors

JBJanina BredeRLRachel LoomesWMWill Mandy

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Overview

Systematic review and meta-analysis discovers gender disparities in mental health conditions among autistic adults, suggesting need for targeted interventions.

Key Points

  • This review aims to identify sex/gender differences in prevalence rates of co-occurring neurodevelopmental and mental health conditions among autistic adults.
  • Conducted a systematic review and meta-analysis of studies reporting prevalence rates for autistic individuals designated as female and male.
  • Evaluated rates of anxiety, eating disorders, trauma-related conditions, and specific neurodevelopmental and externalizing conditions.
  • Autistic individuals designated as female showed higher rates of anxiety, eating disorders, and trauma-related conditions.
  • Autistic individuals designated as male exhibited higher rates of certain neurodevelopmental and externalizing conditions.
  • No significant gender differences were observed for obsessive-compulsive disorder, ADHD, and schizophrenia.

Cite This Study

Brede et al. (2026) studied this question.

synapsesocial.com/papers/6a2a523480c8f91e7f39e3aahttps://doi.org/10.1007/s40489-026-00562-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disproportionate Mental Health Risks in Autistic Females: A Rapid Review with Quantitative and Narrative Syntheses2025
  2. 2Are There Sex or Gender Differences in Autistic Characteristics? An Umbrella Systematic Review2026
  3. 3Sex differences in mental health disorders among autistic men and women: retrospective service audit of a random cohort2026
  4. 4Sex differences in post-traumatic stress disorder risk among autistic individuals: a population-based matched cohort study2026
  5. 5Sex Differences in Psychopathology and Neurocognition in Community Youth With Autism Spectrum Disorder2026