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July 2, 2026Autism Research

Sex Differences in Psychopathology and Neurocognition in Community Youth With Autism Spectrum Disorder

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Authors

RBRan BarzilayChildren's Hospital of PhiladelphiaJKJulia KatzChildren's Hospital of PhiladelphiaRSRahul SoodChildren's Hospital of Philadelphia

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Implication

Randomized trial examines sex differences in psychopathology and neurocognitive performance in youth with autism, indicating important implications for understanding ASD.

Key Points

  • The study aims to investigate sex differences in psychopathology and neurocognitive performance among youth with autism spectrum disorder (ASD).
  • Analyzed a community sample of 218 youths with ASD (171 males, 47 females) and 872 non-ASD controls from the Philadelphia Neurodevelopment Cohort.
  • Compared psychopathology across multiple domains and neurocognitive functions between groups using repeated-measures mixed models.
  • Controlled for variables including age, socioeconomic status, IQ, and ADHD.
  • Males with ASD showed more severe mood and fear symptoms compared to females.
  • Both sexes with ASD had lower performance in social cognition compared to non-ASD peers; however, males exhibited greater difficulties in non-social cognition.
  • The study highlights significant sex-specific manifestations of psychopathology and neurocognitive performance in youth with ASD.

Cite This Study

Barzilay et al. (2026) studied this question.

synapsesocial.com/papers/6a45ffa29ed134303130ff2chttps://doi.org/10.1002/aur.70270
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Also Consider

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  5. 5Prevalence, Symptom Profiles, and Correlates of Mixed Anxiety–Depression in Male and Female Autistic Youth2024