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June 11, 2026CureusOpen Access

Risk Factors for Postoperative Pancreatic Fistula After Pancreaticoduodenectomy: A Single-Center Experience

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Authors

ASAhmed Reza SunyBangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic DisordersSISadia IslamAhsanullah University of Science and TechnologyLHLokman HossainChinese University of Hong Kong

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Overview

Prospective observational study identifies factors predicting POPF in patients undergoing pancreaticoduodenectomy, suggesting optimization strategies.

Key Points

  • This study aims to identify the incidence and independent risk factors for postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD).
  • Prospective observational study conducted with 100 patients who underwent PD
  • Patients classified into POPF and non-POPF groups following ISGPS criteria
  • Multivariate logistic regression utilized to identify independent predictors of POPF.
  • POPF occurred in 28% of patients, with clinically relevant POPF (Grade B/C) in 18%
  • Independent predictors included soft pancreatic texture (adjusted OR: 5.21), pancreatic duct diameter < 3 mm (adjusted OR: 4.36), and serum albumin < 32 g/L (adjusted OR: 3.02)
  • Patients with POPF had longer hospital stays (18.6 vs. 11.9 days) and higher mortality (14.3% vs. 2.8%).

Cite This Study

Suny et al. (2026) studied this question.

synapsesocial.com/papers/6a2a52d980c8f91e7f39ebf9https://doi.org/10.7759/cureus.110526
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  1. 1Risk factors for postoperative pancreatic fistula: Analysis of 539 successive cases of pancreaticoduodenectomy2016 · 165 citations
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  5. 5Diagnostic value of C-reactive protein and procalcitonin for postoperative pancreatic fistula following pancreatoduodenectomy: a systematic review and meta-analysis2021 · 15 citations