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August 23, 2025CancersOpen Access

A Review of Post-Operative Pancreatic Fistula Following Distal Pancreatectomy: Risk Factors, Consequences, and Mitigation Strategies

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Authors

JAJurgis AlvikasSDShakti DahiyaGDGenia Dubrovsky

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Overview

This review highlights risk factors and consequences of post-operative pancreatic fistula, suggesting mitigation strategies to improve outcomes after distal pancreatectomy.

Key Points

  • Post-operative pancreatic fistula affects 20-30% of patients following distal pancreatectomy, leading to serious complications and care delays.
  • Key risk factors for developing post-operative pancreatic fistula include obesity, smoking, and elevated drain amylase levels.
  • Mitigation strategies studied include optimizing pancreatic transection and using somatostatin analogues to reduce complications.
  • Understanding these aspects of post-operative pancreatic fistula may help improve patient outcomes in pancreatic surgery.

Cite This Study

Alvikas et al. (2025) studied this question.

synapsesocial.com/papers/68af5d69ad7bf08b1eae0c77https://doi.org/10.3390/cancers17172741
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and Economic Validation of the International Study Group of Pancreatic Fistula (ISGPF) Classification Scheme2007 · 386 citations
  2. 2Meta-Analysis on the Effect of Pasireotide for Prevention of Postoperative Pancreatic Fistula2020 · 19 citations
  3. 3Effect of Hydrocortisone vs Pasireotide on Pancreatic Surgery Complications in Patients With High Risk of Pancreatic Fistula2020 · 64 citations
  4. 4Safety and performance of a synthetic sealant patch aimed to prevent postoperative pancreatic fistula after distal pancreatectomy (SHIELDS) – Prospective international multicenter phase II study2024 · 4 citations