Diastereoselective synthesis of functionalised indolizino[8,7-b]indoles by a lactamisation/N-acyliminium-cyclisation cascade of β-enamino diketones

We report a diastereoselective, metal-free cascade synthesis of functionalised indolizino[8,7-b]indoles from L-tryptophan-derived β-enamino diketones through a one-pot lactamisation/N-acyliminium cyclisation sequence. This approach delivers fused polycycles in moderate to excellent yields...