What question did this study set out to answer?

To synthesize evidence on the impact of orthodontic treatment on periodontal parameters and microbiota.

June 11, 2026BiomedicinesOpen Access

Orthodontic Treatment-Induced Periodontal, Microbiological, and Local Inflammatory Changes: A Systematic Review and Meta-Analysis

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Systematic review and meta-analysis of periodontal and microbiological changes in orthodontic patients, highlighting implications for practice.

To synthesize evidence on the impact of orthodontic treatment on periodontal parameters and microbiota.
Conducted a systematic review and meta-analysis per PRISMA 2020 guidelines.
Searched PubMed/MEDLINE, Scopus, and Web of Science for relevant studies until March 2026.
Included prospective cohort studies, longitudinal clinical studies, and randomized controlled trials.
Eighteen studies involving 812 patients showed fixed appliances linked to increased plaque index (MD 0.45, 95% CI 0.32–0.58).
Notable rise in gingival index (MD 0.38, 95% CI 0.25–0.51) and bleeding on probing (MD 15.2%, 95% CI 10.1–20.3%).
Elevated IL-1β (MD 1.2, 95% CI 0.8–1.6) and IL-6 (MD 0.9, 95% CI 0.6–1.2) observed in gingival crevicular fluid.

Gavrilescu et al. (2026) studied this question.

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June 11, 2026BiomedicinesOpen Access

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Authors

Systematic review and meta-analysis of periodontal and microbiological changes in orthodontic patients, highlighting implications for practice.

To synthesize evidence on the impact of orthodontic treatment on periodontal parameters and microbiota.
Conducted a systematic review and meta-analysis per PRISMA 2020 guidelines.
Searched PubMed/MEDLINE, Scopus, and Web of Science for relevant studies until March 2026.
Included prospective cohort studies, longitudinal clinical studies, and randomized controlled trials.
Eighteen studies involving 812 patients showed fixed appliances linked to increased plaque index (MD 0.45, 95% CI 0.32–0.58).
Notable rise in gingival index (MD 0.38, 95% CI 0.25–0.51) and bleeding on probing (MD 15.2%, 95% CI 10.1–20.3%).
Elevated IL-1β (MD 1.2, 95% CI 0.8–1.6) and IL-6 (MD 0.9, 95% CI 0.6–1.2) observed in gingival crevicular fluid.

Gavrilescu et al. (2026) studied this question.

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