Key result
This review summarizes the coordination chemistry of nucleotides and acyclic nucleoside phosphonates, highlighting how structural modifications influence metal ion affinity and antiviral activity.
Why the study?
Because nucleotide reactions involve metal ions, understanding the coordination chemistry of nucleotides and acyclic nucleoside phosphonates is essential to clarify mechanisms underlying antiviral activity.
This review elucidates the coordination chemistry and metal ion interactions of acyclic nucleoside phosphonates, providing mechanistic insights into their antiviral activity and polymerase substrate preference.
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Mechanistic insights into ANP metal affinity may guide future designs; leaves open clinical translation of modified compounds.
Sigel et al. (2022) reported a review. Acyclic nucleoside phosphonates (ANPs) was evaluated. This review summarizes the coordination chemistry of nucleotides and acyclic nucleoside phosphonates, highlighting how structural modifications influence metal ion affinity and antiviral activity.
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