Key result
The stability of most M(HPMPA) complexes is enhanced by 5-membered chelates involving the ether oxygen, while Ni2+, Cu2+, and Zn2+ form additional 7-membered chelates at the N3 position.
Why the study?
Acyclic nucleoside phosphonates are medically relevant and require detailed chemical characterization.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications; extends chelation models for HPMPA in coordination chemistry.
Blindauer et al. (2019) studied this question. (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) vs. PMEA, PME, and HPMP was evaluated on Acidity constants and stability constants of metal ion complexes. The stability of most M(HPMPA) complexes is enhanced by 5-membered chelates involving the ether oxygen, while Ni2+, Cu2+, and Zn2+ form additional 7-membered chelates at the N3 position.
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