What is the clinical evidence from this study?

Study design: Observational. Population: Acute myocardial infarction with LV systolic dysfunction (n=100). Intervention: Serum sST2 levels. Primary outcome: Correlation between serum sST2 and left ventricular ejection fraction at 24 weeks (r = -0.23, p=0.026).

What does this research mean for the field?

Serum soluble ST2 levels measured early after acute myocardial infarction correlate with left ventricular ejection fraction at 24 weeks and assist in predicting medium-term ventricular functional recovery. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the relationship between serum sST2 levels and changes in left ventricular function following acute myocardial infarction.

June 11, 2026Journal of the American College of Cardiology

Serum Soluble ST2

Q: What are the key findings of this study?

Serum sST2 levels measured early after acute myocardial infarction correlated significantly with left ventricular ejection fraction at 24 weeks (r = -0.23, p = 0.026).

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Key result

Higher early sST2 levels post-AMI correlate with lower LVEF at 24 weeks.

r = -0.23
P=0.026
n=100

Why the study?

Serum sST2 levels are elevated early after AMI and associated with lower pre-discharge LVEF and adverse outcomes, but their relationship with serial changes in LV function was unknown.

Does serum soluble ST2 level predict left ventricular functional recovery in patients with acute myocardial infarction and LV systolic dysfunction?

Population

100 patients admitted with AMI and resultant LV systolic dysfunction

Comparison

Serial serum sST2 levels over time

Design

Prospective observational study

Follow-up

24 weeks

Authors

RWRobin A.P. WeirHeart Failure / Cardiomyopathy AMAshley M. MillerNational Institute of Mental Health and Neurosciences GMGrace MurphyWellcome Centre for Molecular Parasitology

Discussion

Member takes

Implication

sST2 may aid post-MI LV recovery prediction; extends biomarker correlations with serial CMR but requires outcome validation.

Key Points

To assess the relationship between serum sST2 levels and changes in left ventricular function following acute myocardial infarction.
Measured serum sST2 in 100 patients with myocardial infarction at baseline, 12, and 24 weeks.
Utilized cardiac magnetic resonance imaging to evaluate left ventricular function.
Analyzed levels of norepinephrine, aldosterone, and N-terminal pro-brain natriuretic peptide at each time point.
Median sST2 levels decreased from 263.3 pg/ml at baseline to 140.0 pg/ml at 24 weeks (p < 0.001).
Significant correlation between sST2 and left ventricular ejection fraction at baseline (r = -0.30, p = 0.002) and at 24 weeks (r = -0.23, p = 0.026).
Higher sST2 levels were associated with greater infarct transmurality and correlated with norepinephrine and aldosterone.

Study Design

Type

Observational (n=100)

Structured PICO

Does serum soluble ST2 level predict left ventricular functional recovery in patients with acute myocardial infarction and LV systolic dysfunction?

Population

100 patients (mean age 58.9 years, 23% female) admitted with acute myocardial infarction and resultant LV systolic dysfunction, followed for 24 weeks.

Exposure

Measurement of serum soluble ST2 (sST2) levels at baseline, 12, and 24 weeks

Outcome

Relationship between serum concentrations of sST2 and serial change in left ventricular (LV) function after acute myocardial infarction at 12 and 24 weekssurrogate

Main Result

Effect estimate: r = -0.23

p-value: p=0.026

Measurement of sST2 early after acute myocardial infarction assists in predicting medium-term left ventricular functional recovery and infarct remodeling.

Cite This Study

Weir et al. (2010) conducted an observational in Acute myocardial infarction with LV systolic dysfunction (n=100). Serum sST2 levels was evaluated on Correlation between serum sST2 and left ventricular ejection fraction at 24 weeks (r = -0.23, p=0.026). Serum sST2 levels measured early after acute myocardial infarction correlated significantly with left ventricular ejection fraction at 24 weeks (r = -0.23, p = 0.026).

synapsesocial.com/papers/6a2b2649915c210bd35c5e6f https://doi.org/10.1016/j.jacc.2009.08.047

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Serum Soluble ST2

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Serum Soluble ST2

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider