Key result
Having ≥5 pregnancies was associated with a significantly increased risk of incident stroke compared to having only one pregnancy (HR 1.45; 95% CI 1.18-1.77).
Why the study?
Does high gravidity or parity increase the risk of incident stroke in women?
Population
74,942 Chinese women aged 40 to 70 years at enrollment from the population-based Shanghai Women's Health Study
Comparison
High gravidity or parity vs Low gravidity or parity (1 pregnancy or child)
Design
Cohort
Follow-up
mean 7.3 years
Authors
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High parity may warrant closer stroke surveillance in women; leaves open causality versus confounding in observational data.
Cohort (n=74,942)
Does high gravidity or parity increase the risk of incident stroke in women?
Hazard Ratio: 1.45 (95% CI 1.18–1.77)
High gravidity or parity is associated with an increased risk of stroke in women, potentially due to chronic stress and adverse lifestyle factors related to childrearing.
Zhang et al. (2009) conducted a cohort in Stroke (n=74,942). ≥5 pregnancies vs. 1 pregnancy was evaluated on incident stroke (HR 1.45, 95% CI 1.18 to 1.77). Having ≥5 pregnancies was associated with a significantly increased risk of incident stroke compared to having only one pregnancy (HR 1.45; 95% CI 1.18-1.77).
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