Key result
Acute heart failure carries high post-discharge risks demanding improved management and novel trial designs.
Why the study?
Heart failure resulting in hospitalization is a growing health care burden with high early post-discharge rehospitalization and mortality rates, necessitating investigations into pathophysiologic targets and clinical trial design to improve post-discharge outcomes.
Highlights the high post-discharge event rates in acute heart failure and emphasizes the need for novel approaches to improve post-discharge outcomes.
Post-discharge neurohormonal and renal monitoring may stratify acute HF risk; leaves open whether targeted strategies reduce rehospitalization.
Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.
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Gheorghiade et al. (2009) conducted a review in Acute Heart Failure Syndromes. Acute heart failure syndromes carry high early post-discharge rehospitalization and mortality rates, necessitating improved post-discharge management and novel clinical trial designs.
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