What question did this study set out to answer?

The aim is to evaluate a dual-drug delivery system for improving healing of infected bone defects.

June 12, 2026Materials Today BioOpen Access

Gelatin macromolecular microspheres constructed by microfluidics regulate the TNF/HIF-1 signaling axis to reshape the bone immune microenvironment and enhance infectious bone defect repair

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Randomized trial demonstrates enhanced infectious bone defect repair in a rat model using dual-drug delivery.

The aim is to evaluate a dual-drug delivery system for improving healing of infected bone defects.
Developed gelatin-based microspheres co-loading vancomycin and resveratrol.
Evaluated antibacterial effects in vitro and healing in a rat infected bone defect model.
Utilized network pharmacology and cellular assays to investigate molecular mechanisms.
Microspheres showed effective bacterial clearance and biofilm degradation (p < 0.001).
In vivo, reduced bacterial load and inflammatory response, promoting collagen deposition and bone formation (p < 0.05).
Resveratrol reduced pro-inflammatory markers and regulated the TNF/HIF-1 signaling pathway, enhancing bone healing.

Song et al. (2026) studied this question.

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