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July 26, 2026Journal of NanobiotechnologyOpen Access

Composite antibiotic-loaded nano-platelet vesicle and mineralized hydrogel system for the treatment of infected bone defects

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Authors

ZDZhanqiu DaiWenzhou Medical UniversityZWZi WangHarbin University of Science and TechnologyYWYongcheng WangSir Run Run Shaw Hospital

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Overview

Randomized trial demonstrates effective treatment of infected bone defects using a novel composite system, suggesting significant clinical benefits.

Key Points

  • This research aims to develop and validate a composite system for treating infected bone defects using gentamicin-loaded nano-platelet vesicles and a mineralized hydrogel.
  • Developed an integrated system combining gentamicin-loaded nano-platelet vesicles with calcium phosphate-mineralized hydrogel.
  • Conducted transcriptomic analysis to validate osteogenic differentiation mechanisms of bone marrow mesenchymal stem cells (BMSCs).
  • Performed experimental validation in an infected bone defect model.
  • The composite hydrogel significantly enhanced osteogenic differentiation of BMSCs through activation of the Wnt/β-catenin pathway.
  • The antibiotic-loaded NPVs eliminated bacteria, reducing bacterial-induced osteoclast overactivation.
  • The system provided strong antibacterial activity and effectively modulated the bone microenvironment.

Cite This Study

Dai et al. (2026) studied this question.

synapsesocial.com/papers/6a65a6f2d3aea3239cd780fehttps://doi.org/10.1186/s12951-026-04799-z
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